Ⅰ. Basic information
Name: 2-arm polyethylene glycol succinimide carboxylateAbbreviation: 2-arm PEG-NHS
Molecular weight: There are many molecular weights, such as 2K, 5K, 10K, 20K, 40K, etc., the specific choice depends on the application needs.
Storage conditions: It is recommended to store at -20 ° C and keep dry.
Ⅱ. Chemical structure
2-arm PEG-NHS has two succinimide propionate (SPA) arms that can react with a variety of functional groups, such as amino, sulfhydryl, etc.
Ⅲ. The main application
1. Biological coupling and connection:
2-arm PEG-NHS can be used as a bridge or linker to join two molecules or biomolecules (such as proteins, peptides, nucleic acids, etc.) together. This connection is very common in bioconjugated or bioconjugated reactions.
2. Preparation of biological materials:
The compound can be used to prepare hydrogels, coatings, nanoparticles and other biological materials. The physical and chemical properties of the material can be controlled by adjusting the molecular weight and bonding mode to meet the needs of specific biomedical applications. These biomaterials have a wide range of applications in drug delivery, tissue engineering, biosensors and other fields.
3. Drug delivery and release:
The two-arm polyethylene glycol derivative has good biocompatibility and water solubility, so it can be used in drug delivery systems. By coupling drugs with 2-arm PEG-NHS, targeted delivery and controlled release of drugs can be achieved, improving the therapeutic effect of drugs and reducing side effects.
4. Biomedical research:
In biomedical research, 2-arm PEG-NHS can be used as a probe or marker to study biomolecular interactions, cell signal transduction and other processes. In addition, it can also be used to prepare biosensors or bioimaging reagents.
5. Academic research, innovative drug development, disease research:
This compound also has important applications in academic research, innovative drug development and disease research. For example, it can be used in biological research such as PEG derivative modification of polypeptides, nano modification, as well as the preparation and modification of monoclonal antibodies, polyclonal antibodies, proteins and biological reagents.
Related recommendations:
| Name | Abbreviation |
|---|---|
| 2-arm Methoxypoly(ethylene glycol) | 2-arm PEG-OH |
| 2-arm Methoxypoly(ethylene glycol) carboxylic acid | 2-arm PEG-COOH |
| 2-arm Methoxypoly(ethylene glycol) succinimidyl ester | 2-arm PEG-NHS |
| 2-arm Methoxypoly(ethylene glycol) maleimide | 2-arm PEG-MAL |
| 2-arm Methoxypoly(ethylene glycol) amine | 2-arm PEG-NH2 |
| 2-arm Methoxypoly(ethylene glycol) acetal | 2-arm PEG-Acetal |
| 2-arm Methoxypoly(ethylene glycol) propionaldehyde | 2-arm PEG-CHO |
| 2-arm Methoxypoly(ethylene glycol) dibenzocyclooctynes | 2-arm PEG-DBCO |
| 2-arm Methoxypoly(ethylene glycol) azide | 2-arm PEG-N3 |
| 2-arm Methoxypoly(ethylene glycol) succinimidyl carbonate | 2-arm PEG-SC |
