Industry News
Home /

News

/

Industry News

/Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing
Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing 2024-05-24
Chemical Engineering Journal
Volume 413, 1 June 2021, 127429
https://doi.org/10.1016/j.cej.2020.127429

Engineering poly(ionic liquid) semi-IPN hydrogels with fast antibacterial and anti-inflammatory properties for wound healing

Abstract
The development of treatment of wound healing cannot meet clinical requirements owing to the complex bacteria-infection and inflammatory reaction. It is necessary to develop wound dressings that are fast antibacterial property, anti-inflammation and promoting cell migration and proliferation for shortening wound healing period. In this work, we first synthesized two poly(ionic liquids) (PILs): poly(1-ethyl-3-vinylimidazolium furan-2-carboxylate) (PEIF) and poly(1-butyl-3-vinylimidazolium furan-2-carboxylate) (PBIF). The PILs were then mixed with 5 wt% montmorillonite (MMT) clay and 2-furfurylamine-modified hyaluronic acid (HAF), and chemically crosslinked with four-arm maleimide-polyethylene glycol (Mal4PEG) to form degradable semi-inter penetrate network (semi-IPN) hydrogels. In vitro assays demonstrated that the synthesized semi-IPN hydrogels exhibited high antibacterial activities against Escherichia coli and Staphylococcus aureus due to the high antibacterial activity of PILs. Furthermore, the semi-IPN hydrogel could be quickly degraded, and the PILs exhibited high anti-inflammatory activities when they were released from degraded hydrogels. The degradation solutions of hydrogels contained glycosaminoglycan, which was beneficial to cell proliferation and migration. The in vivo anti-infection results further demonstrated that the semi-IPN hydrogels could kill S. aureus and accelerate the healing of infected wounds.

Related products
Abbreviation: 4-arm-PEG

For more product information, please contact us at:
US Tel: 1-844-782-5734
US Tel: 1-844-QUAL-PEG
CHN Tel: 400-918-9898
Email: sales@sinopeg.com

Copyright © XIAMEN SINOPEG BIOTECH CO., LTD. All Rights Reserved.

Home

Products

News

contact