Chapter 1: Basic Properties
- Abbreviations: 3-arm PEG-NH2; 3arm PEG Amine; 3ARM-PEG-NH2
- Names: Tri-arm polyethylene glycol amine; Tri-arm polyethylene glycol amine
- Molecular weight: Customizable, common values are 0.4k, 0.6k, 1k, 2k, 3.4k, 5k, 10k, etc.
- Physical state: Solid/liquid (depending on molecular weight)
- Solubility: Partially soluble in organic solvents, soluble in water
Chapter 2: Structural Features
- Structural composition: This compound has three polyethylene glycol (PEG) arms, each terminating with an amino (-NH2) functional group. This unique structure provides 3-arm PEG-NH2 with high reactivity.
- Role of PEG chains: PEG chains are known for their hydrophilicity and biocompatibility, significantly enhancing the solubility and biocompatibility of compounds while reducing their immunogenicity.
- Amino functional group: The amino (-NH2) group is a basic functional group capable of reacting with molecules containing carboxyl (-COOH), aldehyde, or ketone groups, forming stable chemical bonds such as amide bonds.
Chapter 3: Applications
- Drug delivery: Due to excellent biocompatibility and water solubility of PEG, 3-arm PEG-NH2 significantly enhances the solubility and stability of biologically active molecules linked to it, playing a crucial role in drug delivery systems.
- Biomedical imaging: This compound can be used in the field of biomedical imaging to better observe and study processes within organisms.
- Biomaterials: 3-arm PEG-NH2 is also utilized in preparing biologically functional materials such as tissue engineering scaffolds.
Related recommendations:
| Name | Abbreviation |
|---|---|
| 3-arm Poly(ethylene glycol) | 3-arm PEG-OH |
| 3-arm Poly(ethylene glycol) amine | 3-arm PEG-NH2 |
| 3-arm Poly(ethylene glycol) carboxylic acid | 3-arm PEG-CM |
| 3-arm Poly(ethylene glycol) succinate acid | 3-arm PEG-SA |
| 3-arm Poly(ethylene glycol) thiol | 3-arm PEG-SH |
| 3-arm Poly(ethylene glycol) propionaldehyde | 3-arm PEG-pALD |
|
3-arm Poly(ethylene glycol) maleimide(ether) |
3-arm PEG-MAL(ether) |
| 3-arm Poly(ethylene glycol) succinimidyl carbonate | 3-arm PEG-SC |
| 3-arm Poly(ethylene glycol) azide | 3-arm PEG-N3 |
| 3-arm Poly(ethylene glycol) amine hydrochloride salt | 3-arm PEG-NH2·HCl |
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